Supercooling, or overcooling, is a state where a substance is cooled to a temperature below its freezing point but still remains in a liquid state. Under normal conditions, a substance turns solid at a certain temperature (freezing point). However, sometimes substances can remain in a liquid state even below their freezing points – this is called supercooling.

To understand how supercooling is possible, it is important to know that freezing a substance is usually a two-stage process: first, the substance cools, and then it solidifies. The solidification process usually requires a “nucleus” or a point where solidification begins. If this nucleation event does not occur, the substance can remain liquid even below the freezing point.

Supercooling poses a significant problem during the freezing process of biological samples. Cells can be damaged in a state of supercooling. When cells remain below the freezing point, the water inside them begins to crystallize and rupture the cell membrane. This can lead to cell death. Therefore, during the freezing of hematopoietic stem cells, for example, special techniques and equipment are used to prevent supercooling.

The supercooling phenomenon is an undesirable situation during the freezing of hematopoietic stem cells because it can increase the effect of factors such as crystallization and mechanical stress that may occur during the freezing of stem cells. This situation leads to a loss of cell viability. Jacketed freezers are a method used to prevent the supercooling phenomenon.

Jacketed freezers minimize the risk of supercooling, ensuring the safe and effective frozen storage of hematopoietic stem cells. This technology helps to preserve cells healthily and ensures their subsequent use.

In conclusion, supercooling is an important factor to consider in the process of freezing and storing hematopoietic stem cells. Jacketed freezers control this situation, ensuring the safe and effective freezing and storage of hematopoietic stem cells.

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